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Thomsen Laboratory
of Biomolecular Pharmacology

Publications

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Arrestin-Biased AT1R Agonism Induces Acute Catecholamine Secretion Through TRPC3 Coupling

Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu CX, Xiao P, Liu CY, Thomsen ARB, Cahill III TJ, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun J-P (2017). Nature Communications, 8:14335.

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journal article, 2017ScienceSitesJanuary 6, 2020
GPCR–G Protein–β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

Thomsen ARB*, Plouffe B*, Cahill III TJ*, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L-Y, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ (2016). Cell 166:907-19.
*co-first authors
(Highlighted in Trends Biochem Sci and Angew Chem Int Ed, Recommended by Faculty of 1000)

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2016, journal articleScienceSitesJanuary 6, 2020
Conformationally Selective RNA Aptamers Allosterically Modulate the β2-Adrenoceptor

Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill III TJ, Dennison SM, Staus DP, Thomsen ARB, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ (2016). Nature Chemical Biology. 12:709-16.

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journal article, 2016ScienceSitesJanuary 6, 2020
Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism at a G Protein-Coupled Receptor (GPCR)

Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Thomsen ARB, Zhu X, Kleist A, Costa T, Lefkowitz RJ (2014). Journal of Biological Chemistry, 289:14211-24.

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2014, journal articleScienceSitesJanuary 6, 2020
G Protein-Coupled Receptor Signaling Analysis using Homogenous Time-Resolved Förster Resonance Energy Transfer (HTRF®) Technology

Nørskov-Lauritsen L, Thomsen ARB, Bräuner-Osborne H (2014). International Journal of Molecular Sciences, 15:2554-72.

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2014, journal articleScienceSitesJanuary 6, 2020
Recent Developments in Biased Agonism

Wisler JW, Xiao K, Thomsen ARB, Lefkowitz RJ (2014). Current Opinion in Cell Biology, 27:18-24.

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journal article, 2014ScienceSitesJanuary 6, 2020
Delineation of the GPRC6A Receptor Signaling Pathways using a Mammalian Cell Line Stably Expressing the Receptor

Jacobsen SE*, Nørskov-Lauritsen L*, Thomsen ARB*, Smajilovic S, Wellendorph P, Larsson NH, Lehmann A, Bhatia VK, Bräuner-Osborne H (2013). Journal of Pharmacology and Experimental Therapeutics, 347:298-309.
*co-first authors

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2013, journal articleScienceSitesJanuary 6, 2020
Synthesis of the Calcilytic Ligand NPS 2143

Johansson H, Cailly T, Thomsen ARB, Bräuner-Osborne H, Sejer Pedersen D (2013). Beilstein Journal of Organic Chemistry, 9:1383-7.

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2013, journal articleScienceSitesJanuary 6, 2020
CaSR-Mediated Interactions Between Calcium and Magnesium Homeostasis in Mice

Quinn SJ, Thomsen ARB, Egbuna O, Pang J, Baxi K, Karapils A, Goltzman D, Pollak M, Brown EM (2013). American Journal of Physiology-Endocrinology and Metabolism, 304:E724-33.

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journal article, 2013ScienceSitesJanuary 6, 2020
Interactions Between Calcium and Phosphorus in the Regulation of the Production of Fibroblast Growth Factor 23 In Vivo

Quinn SJ*, Thomsen ARB*, Pang JL, Kantham L, Bräuner-Osborne H, Pollak M, Goltzman D, Brown EM (2012). American Journal of Physiology-Endocrinology and Metabolism, 304:E310-20.
*co-first authors

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2012, journal articleScienceSitesJanuary 6, 2020
Strontium is a Biased Agonist of the Calcium-Sensing Receptor in Rat Medullary Thyroid Carcinoma 6-23 Cells

Thomsen ARB, Worm J, Jacobsen SE, Stahlhut M, Latta M, Bräuner-Osborne H (2012). Journal of Pharmacology and Experimental Therapeutics, 343:638-49.

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2012, journal articleScienceSitesJanuary 6, 2020
Allosteric Modulation and Differential Signaling of the Calcium-Sensing Receptor

Thomsen ARB, Smajilovic S, Brauner-Osborne H (2012). Current Drug Targets, 13:1324-35.

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journal article, 2012ScienceSitesJanuary 6, 2020
Biased Agonism of the CalciumSensing Receptor

Thomsen ARB, Hvidtfeldt M, Brauner-Osborne H (2011). Cell Calcium 51:107-16.

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2011, journal articleScienceSitesJanuary 6, 2020
Chemogenomic Discovery of Novel Allosteric Antagonists at the GPRC6A Receptor

Gloriam DE*, Wellendorph P*, Johansen LD*, Thomsen ARB, Phonekeo K, Brauner-Osborne H (2011). Chemistry & Biology, 18:1489-98.
*co-first authors

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2011, journal articleScienceSitesJanuary 6, 2020
E-cadherin Contributes to the Bystander Effect of TK/GCV Suicide Therapy and Enhances its Antitumoral Activity in Pancreatic Cancer Models

Garcia-Rodríguez L, Abate-Daga D, Rojas A, González JR, Fillat C (2011). Gene Therapy, 18:73-81.

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journal article, 2011ScienceSitesJanuary 6, 2020
Sarcomere Gene Mutations in Hypertrophic Cardiomyopathy: Diagnostic Yield, Interpretation and Clinical Usefulness

Andersen PS, Havndrup O, Bundgaard H, Hougs L, Sørensen KM, Larsen LA, Hedley P, Thomsen ARB, Moolman-Smook J, Christiansen M (2009). Human Mutation, 30:363-70.

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journal article, 2009ScienceSitesJanuary 6, 2020
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Contact

Alex R.B. Thomsen
Assistant Professor
Department of Molecular Pathobiology
433 1st Avenue, Room 706
New York, NY 10010
Email: art8@nyu.edu
Phone: 212-998-9550

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